Alle Draft Picks aus der ersten Runde im NFL Draft 2021 auf einen Blick.
| Pick | Team | Pick |
| 1 | Jacksonville Jaguars | Trevor Lawrence, QB, Clemson |
| 2 | New York Jets | Zach Wilson, QB, BYU |
| 3 | San Francisco 49ers | Trey Lance, QB, NDSU |
| 4 | Atlanta Falcons | Kyle Pitts, TE, Florida |
| 5 | Cincinnati Bengals | Ja’Marr Chase, WR, LSU |
| 6 | Miami Dolphins | Jaylen Waddle, WR, Alabama |
| 7 | Detroit Lions | Penei Sewell, OT, Oregon |
| 8 | Carolina Panthers | Jaycee Horn, CB, South Carolina |
| 9 | Denver Broncos | Patrick Surtain II, CB, Alabama |
| 10 | Philadelphia Eagles | DeVonta Smith, WR, Alabama |
| 11 | Chicago Bears | Justin Fields, QB, Ohio State |
| 12 | Dallas Cowboys | Micah Parsons, LB, Penn State |
| 13 | Los Angeles Chargers | Rashawn Slater, OT, Northwestern |
| 14 | New York Jets | Alijah Vera-Tucker, OG, USC |
| 15 | New England Patriots | Mac Jones, QB, Alabama |
| 16 | Arizona Cardinals | Zaven Collins, LB, Tulsa |
| 17 | Las Vegas Raiders | Alex Leatherwood, OT, Alabama |
| 18 | Miami Dolphins | Jaelan Phillips, DE, Miami |
| 19 | Washington Football Team | Jamin Davis, LB, Kentucky |
| 20 | New York Giants | Kadarius Toney, WR, Florida |
| 21 | Indianapolis Colts | Kwity Paye, DE, Michigan |
| 22 | Tennessee Titans | Caleb Farley, CB, Virginia Tech |
| 23 | Minnesota Vikings | Christian Darrisaw, OT, Virginia Tech |
| 24 | Pittsburgh Steelers | Najee Harris, RB, Alabama |
| 25 | Jacksonville Jaguars | Travis Etienne, RB, Clemson |
| 26 | Cleveland Browns | Greg Newsome II, CB, Northwestern |
| 27 | Baltimore Ravens | Rashod Bateman, WR, Minnesota |
| 28 | New Orleans Saints | Payton Turner, DE, Houston |
| 29 | Green Bay Packers | Eric Stokes, CB, Georgia |
| 30 | Buffalo Bills | Gregory Rousseau, EDGE, Miami |
| 31 | Baltimore Ravens | Jayson Oweh, EDGE, Penn State |
| 32 | Tampa Bay Buccaneers | Joe Tryon, EDGE, Washington |
